THE DCAS9-BASED GENOME EDITING IN PLASMODIUM YOELII

The dCas9-based genome editing in Plasmodium yoelii

ABSTRACTGenetic editing is a powerful tool for functional characterization of genes in various organisms.With its simplicity and specificity, the CRISPR-Cas9 technology has become a popular editing tool, which introduces bauhaus stencil site-specific DNA double-strand breaks (DSBs), and then leverages the endogenous repair pathway for DSB repair vi

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The Italian Neo-Idealists and Federigo Enriques

The controversy that between 1908 and 1912 saw Benedetto Croce and delta gamma blanket Giovanni Gentile opposed on one side and Federigo Enriques on the other did not actually have a conclusive episode, but its end was perceived, for its results on culture, on society and teaching in Italy, as a "defeat" of Enriques.A more careful examination of th

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Reversal of the Halo Effect: Prolonged Participation in Comprehensive Care for Joint Replacement Negatively Impacts Revision Metrics

Background: The downstream regional effect of the Comprehensive Care for Joint Replacement (CJR) program on care pathway-adjacent patients, including revision arthroplasty patients, is poorly understood.Prior studies have demonstrated that care pathways targeting primary total joint arthroplasty may produce a halo effect, arm tray for wheelchair im

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